| Identification |
|---|
| HMDB Protein ID
| CDBP02657 |
| Secondary Accession Numbers
| Not Available |
| Name
| Anoctamin-4 |
| Description
| Not Available |
| Synonyms
|
- Transmembrane protein 16D
|
| Gene Name
| ANO4 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in chloride channel activity |
| Specific Function
| May act as a calcium-activated chloride channel |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Membrane
- Multi-pass membrane protein (Potential)
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 12q23.1 |
| SNPs
| ANO4 |
| Gene Sequence
|
>2868 bp
ATGGAGGCAAGCTCTTCTGGAATCACTAATGGAAAAACCAAAGTCTTCCACCCAGAAGGA
GGTGTGGATTTGCAAGGCTACCAGCTGGATATGCAAATACTACCTGACGGGCCAAAGAGT
GATGTGGACTTTTCAGAGATTCTTAATGCAATACAAGAAATGGCCAAGGATGTCAATATT
CTTTTTGATGAATTAGAAGCTGTCAGCAGTCCTTGCAAAGATGACGATTCTCTTCTTCAC
CCTGGAAACCTGACTAGTACTTCAGATGATGCCAGCAGATTGGAAGCCGGGGGAGAGACA
GTGCCAGAAAGAAACAAATCAAATGGACTTTACTTTCGAGATGGAAAGTGTCGAATTGAC
TACATCCTTGTGTACAGAAAATCCAACCCCCAGACTGAAAAGAGAGAAGTATTTGAAAGA
AACATTAGAGCAGAAGGATTGCAAATGGAGAAAGAGTCCTCTCTAATAAATAGTGACATT
ATCTTTGTGAAGTTGCATGCCCCATGGGAAGTCCTTGGAAGATATGCAGAACAAATGAAT
GTAAGAATGCCTTTCAGGAGAAAAATCTATTACCTGCCCCGCCGTTACAAGTTCATGAGC
AGGATCGATAAACAAATAAGCAGGTTTCGGAGATGGTTACCTAAGAAGCCAATGAGGCTG
GACAAGGAGACACTGCCAGACCTGGAGGAGAATGACTGCTACACTGCCCCTTTCAGCCAG
CAAAGGATCCATCACTTCATCATACACAACAAAGAAACGTTCTTCAACAATGCCACAAGA
AGTAGAATCGTGCATCACATTTTACAAAGAATAAAATATGAAGAAGGAAAAAACAAGATT
GGTCTGAATCGTTTGCTTACCAATGGCTCCTATGAAGCTGCGTTTCCCCTGCATGAGGGA
AGTTATAGAAGTAAAAACTCCATTCGAACCCATGGAGCAGAAAACCACCGACATCTACTC
TATGAGTGCTGGGCCTCCTGGGGCGTGTGGTATAAATACCAACCTTTGGATCTTGTAAGG
CGGTACTTTGGAGAGAAGATTGGGTTATATTTTGCCTGGTTGGGCTGGTACACCGGCATG
CTCTTCCCAGCTGCCTTCATTGGATTGTTTGTCTTTTTGTATGGCGTCACCACTCTGGAT
CACAGCCAAGTCAGTAAAGAAGTCTGCCAAGCTACAGATATCATCATGTGTCCTGTGTGT
GATAAATACTGTCCATTCATGAGGCTGTCAGACAGCTGTGTATATGCCAAGGTAACCCAC
CTTTTTGACAATGGAGCCACTGTCTTCTTTGCTGTTTTCATGGCAGTCTGGGCAACAGTT
TTCCTGGAGTTTTGGAAAAGACGGCGAGCAGTAATTGCTTATGACTGGGATTTGATAGAC
TGGGAAGAAGAGGAGGAAGAAATACGACCCCAGTTTGAAGCCAAGTATTCCAAGAAAGAG
CGGATGAATCCAATTTCTGGAAAGCCAGAACCTTATCAAGCATTTACAGATAAATGCAGC
AGACTTATCGTTTCTGCATCTGGAATATTTTTTATGATCTGCGTGGTGATTGCTGCCGTG
TTCGGGATCGTCATTTACCGGGTGGTGACTGTCAGCACTTTCGCTGCCTTTAAGTGGGCG
TTAATCAGGAATAACTCTCAGGTTGCAACCACAGGGACTGCTGTGTGCATCAACTTCTGT
ATCATTATGTTGCTGAATGTGCTCTATGAAAAAGTTGCCCTGCTTCTGACGAATTTAGAA
CAGCCTCGCACAGAGTCTGAGTGGGAGAACAGCTTCACCCTGAAAATGTTTCTTTTTCAG
TTTGTCAATCTGAACAGCTCCACATTTTACATCGCATTCTTCCTCGGAAGATTTACAGGA
CACCCAGGTGCCTACTTGAGGCTGATAAACAGGTGGAGACTAGAAGAGTGCCACCCTAGT
GGATGCCTTATTGATCTGTGTATGCAAATGGGTATTATAATGGTGCTAAAGCAGACCTGG
AATAATTTCATGGAACTTGGCTACCCGTTAATTCAGAATTGGTGGACTAGAAGAAAAGTA
CGACAAGAACATGGACCTGAAAGGAAAATAAGTTTCCCACAATGGGAAAAGGACTATAAC
CTTCAGCCGATGAATGCCTATGGACTCTTCGATGAATACTTAGAAATGATTCTTCAGTTT
GGATTCACAACTATCTTTGTGGCAGCTTTTCCCCTAGCACCACTTCTGGCCTTACTGAAT
AACATAATTGAAATTCGACTTGATGCTTACAAATTTGTCACACAGTGGAGGAGACCTTTA
GCTTCAAGGGCCAAAGACATAGGAATTTGGTATGGAATTCTTGAAGGCATTGGAATTCTC
TCTGTTATCACAAATGCATTTGTCATAGCGATAACATCTGACTTTATCCCTCGCTTGGTG
TATGCTTATAAGTATGGACCTTGTGCAGGCCAAGGAGAAGCTGGGCAAAAGTGCATGGTT
GGCTATGTGAATGCCAGCTTGTCTGTATTTCGAATTTCTGACTTTGAGAACCGATCTGAG
CCTGAATCTGATGGCAGTGAGTTCTCGGGGACTCCTCTTAAGTACTGCAGATACCGGGAC
TACCGTGACCCGCCTCATTCACTGGTGCCCTATGGCTACACACTGCAGTTTTGGCATGTC
CTAGCTGCTCGATTAGCTTTTATCATTGTCTTTGAGCACCTCGTGTTTTGTATAAAGCAC
CTCATTTCATATCTGATCCCAGACCTCCCAAAAGACCTAAGGGATCGAATGAGAAGAGAG
AAGTACTTGATTCAGGAGATGATGTATGAAGCAGAACTGGAACGTCTCCAGAAGGAACGA
AAGGAGAGGAAGAAGAATGGAAAAGCACACCACAACGAGTGGCCGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 955 |
| Molecular Weight
| 111460.6 |
| Theoretical pI
| 8.26 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["353-373", "425-445", "506-526", "548-568", "596-616", "716-736", "769-789", "886-906"]
|
| Protein Sequence
|
>Anoctamin-4
MEASSSGITNGKTKVFHPEGGVDLQGYQLDMQILPDGPKSDVDFSEILNAIQEMAKDVNI
LFDELEAVSSPCKDDDSLLHPGNLTSTSDDASRLEAGGETVPERNKSNGLYFRDGKCRID
YILVYRKSNPQTEKREVFERNIRAEGLQMEKESSLINSDIIFVKLHAPWEVLGRYAEQMN
VRMPFRRKIYYLPRRYKFMSRIDKQISRFRRWLPKKPMRLDKETLPDLEENDCYTAPFSQ
QRIHHFIIHNKETFFNNATRSRIVHHILQRIKYEEGKNKIGLNRLLTNGSYEAAFPLHEG
SYRSKNSIRTHGAENHRHLLYECWASWGVWYKYQPLDLVRRYFGEKIGLYFAWLGWYTGM
LFPAAFIGLFVFLYGVTTLDHSQVSKEVCQATDIIMCPVCDKYCPFMRLSDSCVYAKVTH
LFDNGATVFFAVFMAVWATVFLEFWKRRRAVIAYDWDLIDWEEEEEEIRPQFEAKYSKKE
RMNPISGKPEPYQAFTDKCSRLIVSASGIFFMICVVIAAVFGIVIYRVVTVSTFAAFKWA
LIRNNSQVATTGTAVCINFCIIMLLNVLYEKVALLLTNLEQPRTESEWENSFTLKMFLFQ
FVNLNSSTFYIAFFLGRFTGHPGAYLRLINRWRLEECHPSGCLIDLCMQMGIIMVLKQTW
NNFMELGYPLIQNWWTRRKVRQEHGPERKISFPQWEKDYNLQPMNAYGLFDEYLEMILQF
GFTTIFVAAFPLAPLLALLNNIIEIRLDAYKFVTQWRRPLASRAKDIGIWYGILEGIGIL
SVITNAFVIAITSDFIPRLVYAYKYGPCAGQGEAGQKCMVGYVNASLSVFRISDFENRSE
PESDGSEFSGTPLKYCRYRDYRDPPHSLVPYGYTLQFWHVLAARLAFIIVFEHLVFCIKH
LISYLIPDLPKDLRDRMRREKYLIQEMMYEAELERLQKERKERKKNGKAHHNEWP
|
| External Links |
|---|
| GenBank ID Protein
| 80478369 |
| UniProtKB/Swiss-Prot ID
| Q32M45 |
| UniProtKB/Swiss-Prot Entry Name
| ANO4_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC109308 |
| GeneCard ID
| ANO4 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |