Showing Protein Lipid phosphate phosphatase-related protein type 4 (CDBP02558)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 3 compounds
Identification
HMDB Protein ID CDBP02558
Secondary Accession Numbers Not Available
Name Lipid phosphate phosphatase-related protein type 4
Description Not Available
Synonyms
  1. Brain-specific phosphatidic acid phosphatase-like protein 1
  2. PRG-1
  3. Plasticity-related gene 1 protein
Gene Name LPPR4
Protein Type Enzyme
Biological Properties
General Function Involved in catalytic activity
Specific Function Hydrolyzes lysophosphatidic acid (LPA). Facilitates axonal outgrowth during development and regenerative sprouting. In the outgrowing axons acts as an ecto-enzyme and attenuates phospholipid-induced axon collapse in neurons and facilitates outgrowth in the hippocampus.
GO Classification
Biological Process
phospholipid dephosphorylation
inner ear development
axonogenesis
Cellular Component
external side of plasma membrane
integral to plasma membrane
Component
membrane
cell part
Function
catalytic activity
Molecular Function
lipid phosphatase activity
phosphatidate phosphatase activity
Cellular Location
  1. Membrane
  2. Multi-pass membrane protein (Potential)
Pathways
Gene Properties
Chromosome Location 1
Locus 1p21.2
SNPs LPPR4
Gene Sequence 
>2292 bp
ATGCAGCGCGCTGGCTCCAGCGGTGGCCGCGGGGAATGTGACATCAGCGGCGCCGGGCGC
TTGGGGCTGGAGGAGGCAGCTCGCCTCAGCTGCGCTGTGCACACCTCGCCCGGGGGAGGA
CGCAGACCCGGGCAGGCGGCAGGGATGTCGGCGAAGGAGAGGCCAAAGGGCAAAGTGATC
AAGGACAGCGTCACCCTCCTGCCCTGCTTTTATTTCGTCGAGTTGCCTATATTGGCATCA
TCGGTGGTTAGCCTCTATTTCCTCGAACTCACAGATGTCTTCAAACCTGTGCACTCTGGA
TTTAGCTGCTATGACCGGAGTCTTAGCATGCCGTACATTGAACCAACCCAGGAGGCAATT
CCATTCCTCATGTTGCTTAGCTTGGCTTTTGCTGGACCTGCAATTACGATTATGGTAGGA
GAAGGAATTCTCTACTGTTGCCTCTCCAAAAGAAGAAATGGGGTCGGACTAGAGCCCAAC
ATTAATGCTGGAGGCTGCAACTTCAATTCCTTCCTCAGACGAGCTGTCAGATTCGTTGGT
GTTCATGTATTTGGATTATGCTCTACAGCTCTCATTACAGATATCATACAGCTGTCCACA
GGATATCAAGCACCTTACTTTCTGACTGTGTGCAAACCAAACTATACCTCTCTGAATGTA
TCTTGCAAAGAAAATTCCTACATTGTGGAAGATATTTGCTCAGGATCTGACCTCACAGTT
ATCAACAGTGGCAGAAAGTCCTTCCCTTCTCAACATGCAACCCTTGCTGCCTTTGCAGCT
GTGTATGTTTCGATGTACTTCAATTCCACATTAACGGATTCCTCTAAGCTTCTGAAACCT
CTCTTGGTCTTCACATTTATCATCTGTGGAATAATCTGCGGGCTAACACGGATAACTCAG
TATAAGAACCACCCAGTTGATGTCTATTGTGGCTTTTTAATAGGAGGAGGAATTGCACTG
TACTTGGGCTTGTATGCTGTGGGGAATTTCCTGCCCAGTGATGAGAGTATGTTTCAGCAC
AGAGACGCCCTCAGGTCTCTGACAGACCTCAATCAAGATCCCAACCGACTTTTATCTGCT
AAAAATGGTAGCAGCAGTGATGGAATTGCTCATACAGAAGGCATCCTCAACCGAAACCAC
AGAGATGCTAGCTCTCTGACAAATCTCAAAAGAGCAAATGCTGATGTGGAAATCATTACT
CCACGGAGCCCCATGGGGAAGGAGAACATGGTTACCTTCAGCAATACCTTGCCGCGAGCC
AATACCCCATCTGTAGAAGACCCTGTCAGAAGAAATGCGAGCATTCATGCCTCTATGGAT
TCCGCTCGATCAAAGCAGCTCCTCACCCAGTGGAAGAATAAGAATGAAAGTCGAAAGTTG
TCCTTGCAAGTTATAGAGCCTGAGCCTGGGCAGTCACCACCCAGATCCATAGAAATGAGG
TCAAGCTCAGAGCCATCGAGGGTAGGGGTGAATGGAGACCACCATGGTCCTGGCAATCAG
TACCTCAAAATCCAGCCTGGCGCTGTCCCCGGATGTAACAACAGCATGCCTGGAGGGCCA
AGAGTGTCCATTCAGTCCCGTCCTGGGTCCTCACAGTTGGTGCACATCCCTGAGGAGACT
CAGGAAAACATAAGCACCTCCCCCAAAAGCAGCTCTGCTCGGGCCAAGTGGTTAAAAGCT
GCTGAAAAGACTGTGGCCTGTAACAGAAGCAACAGCCAGCCCCGAATCATGCAAGTCATA
GCCATGTCCAAGCAGCAGGGTGTCCTCCAAAGCAGCCCCAAGAACACTGAAGGCAGCACG
GTCTCCTGCACTGGCTCCATCCGCTATAAAACCTTGACAGACCATGAGCCCAGTGGGATA
GTGAGGGTTGAGGCTCACCCAGAGAACAACAGGCCCATCATACAGATCCCGTCCACTGAA
GGTGAAGGCAGTGGCTCCTGGAAGTGGAAAGCCCCTGAAAAGGGCAGCCTTCGCCAAACT
TACGAGCTCAACGATCTCAACAGGGACTCAGAAAGCTGTGAGTCTCTGAAAGACAGCTTT
GGTTCTGGAGATCGCAAGAGAAGCAACATTGATAGCAATGAGCATCACCACCACGGAATT
ACCACCATCCGCGTCACCCCAGTAGAGGGCAGCGAAATTGGCTCAGAGACGCTGTCCATT
TCTTCTTCCCGCGACTCCACCCTGCGGAGAAAGGGCAATATCATTCTAATCCCTGAAAGA
AGCAACAGCCCCGAAAACACTAGAAATATCTTCTACAAAGGAACCTCCCCCACACGGGCT
TATAAGGATTGA
Protein Properties
Number of Residues 763
Molecular Weight 76553.42
Theoretical pI 8.755
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence 
>Lipid phosphate phosphatase-related protein type 4
MQRAGSSGGRGECDISGAGRLGLEEAARLSCAVHTSPGGGRRPGQAAGMSAKERPKGKVI
KDSVTLLPCFYFVELPILASSVVSLYFLELTDVFKPVHSGFSCYDRSLSMPYIEPTQEAI
PFLMLLSLAFAGPAITIMVGEGILYCCLSKRRNGVGLEPNINAGGCNFNSFLRRAVRFVG
VHVFGLCSTALITDIIQLSTGYQAPYFLTVCKPNYTSLNVSCKENSYIVEDICSGSDLTV
INSGRKSFPSQHATLAAFAAVYVSMYFNSTLTDSSKLLKPLLVFTFIICGIICGLTRITQ
YKNHPVDVYCGFLIGGGIALYLGLYAVGNFLPSDESMFQHRDALRSLTDLNQDPNRLLSA
KNGSSSDGIAHTEGILNRNHRDASSLTNLKRANADVEIITPRSPMGKENMVTFSNTLPRA
NTPSVEDPVRRNASIHASMDSARSKQLLTQWKNKNESRKLSLQVIEPEPGQSPPRSIEMR
SSSEPSRVGVNGDHHGPGNQYLKIQPGAVPGCNNSMPGGPRVSIQSRPGSSQLVHIPEET
QENISTSPKSSSARAKWLKAAEKTVACNRSNSQPRIMQVIAMSKQQGVLQSSPKNTEGST
VSCTGSIRYKTLTDHEPSGIVRVEAHPENNRPIIQIPSTEGEGSGSWKWKAPEKGSLRQT
YELNDLNRDSESCESLKDSFGSGDRKRSNIDSNEHHHHGITTIRVTPVEGSEIGSETLSI
SSSRDSTLRRKGNIILIPERSNSPENTRNIFYKGTSPTRAYKD
GenBank ID Protein 33636722
UniProtKB/Swiss-Prot ID Q7Z2D5
UniProtKB/Swiss-Prot Entry Name LPPR4_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_014839.4
GeneCard ID LPPR4
GenAtlas ID Not Available
HGNC ID Not Available
References
General References Not Available