| Identification |
|---|
| HMDB Protein ID
| CDBP02549 |
| Secondary Accession Numbers
| Not Available |
| Name
| Lysophosphatidic acid receptor 3 |
| Description
| Not Available |
| Synonyms
|
- LPA receptor 3
- LPA-3
- Lysophosphatidic acid receptor Edg-7
|
| Gene Name
| LPAR3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in G-protein coupled receptor protein signaling pathway |
| Specific Function
| Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. May play a role in the development of ovarian cancer. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins |
| GO Classification
|
| Component |
| membrane part |
| intrinsic to membrane |
| integral to membrane |
| cell part |
| Function |
| bioactive lipid receptor activity |
| lysosphingolipid and lysophosphatidic acid receptor activity |
| receptor activity |
| transmembrane receptor activity |
| molecular transducer activity |
| signal transducer activity |
| g-protein coupled receptor activity |
| Process |
| signaling |
| signaling pathway |
| cell surface receptor linked signaling pathway |
| g-protein coupled receptor protein signaling pathway |
|
| Cellular Location
|
- Cell membrane
- Multi-pass membrane protein
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Lysophosphatidic Acid LPA3 Signalling |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 1p22.3 |
| SNPs
| LPAR3 |
| Gene Sequence
|
>1062 bp
ATGAATGAGTGTCACTATGACAAGCACATGGACTTTTTTTATAATAGGAGCAACACTGAT
ACTGTCGATGACTGGACAGGAACAAAGCTTGTGATTGTTTTGTGTGTTGGGACGTTTTTC
TGCCTGTTTATTTTTTTTTCTAATTCTCTGGTCATCGCGGCAGTGATCAAAAACAGAAAA
TTTCATTTCCCCTTCTACTACCTGTTGGCTAATTTAGCTGCTGCCGATTTCTTCGCTGGA
ATTGCCTATGTATTCCTGATGTTTAACACAGGCCCAGTTTCAAAAACTTTGACTGTCAAC
CGCTGGTTTCTCCGTCAGGGGCTTCTGGACAGTAGCTTGACTGCTTCCCTCACCAACTTG
CTGGTTATCGCCGTGGAGAGGCACATGTCAATCATGAGGATGCGGGTCCATAGCAACCTG
ACCAAAAAGAGGGTGACACTGCTCATTTTGCTTGTCTGGGCCATCGCCATTTTTATGGGG
GCGGTCCCCACACTGGGCTGGAATTGCCTCTGCAACATCTCTGCCTGCTCTTCCCTGGCC
CCCATTTACAGCAGGAGTTACCTTGTTTTCTGGACAGTGTCCAACCTCATGGCCTTCCTC
ATCATGGTTGTGGTGTACCTGCGGATCTACGTGTACGTCAAGAGGAAAACCAACGTCTTG
TCTCCGCATACAAGTGGGTCCATCAGCCGCCGGAGGACACCCATGAAGCTAATGAAGACG
GTGATGACTGTCTTAGGGGCGTTTGTGGTATGCTGGACCCCGGGCCTGGTGGTTCTGCTC
CTCGACGGCCTGAACTGCAGGCAGTGTGGCGTGCAGCATGTGAAAAGGTGGTTCCTGCTG
CTGGCGCTGCTCAACTCCGTCGTGAACCCCATCATCTACTCCTACAAGGACGAGGACATG
TATGGCACCATGAAGAAGATGATCTGCTGCTTCTCTCAGGAGAACCCAGAGAGGCGTCCC
TCTCGCATCCCCTCCACAGTCCTCAGCAGGAGTGACACAGGCAGCCAGTACATAGAGGAT
AGTATTAGCCAAGGTGCAGTCTGCAATAAAAGCACTTCCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 353 |
| Molecular Weight
| 40128.1 |
| Theoretical pI
| 9.75 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["32-52", "68-88", "102-124", "147-167", "187-207", "241-261", "277-297"]
|
| Protein Sequence
|
>Lysophosphatidic acid receptor 3
MNECHYDKHMDFFYNRSNTDTVDDWTGTKLVIVLCVGTFFCLFIFFSNSLVIAAVIKNRK
FHFPFYYLLANLAAADFFAGIAYVFLMFNTGPVSKTLTVNRWFLRQGLLDSSLTASLTNL
LVIAVERHMSIMRMRVHSNLTKKRVTLLILLVWAIAIFMGAVPTLGWNCLCNISACSSLA
PIYSRSYLVFWTVSNLMAFLIMVVVYLRIYVYVKRKTNVLSPHTSGSISRRRTPMKLMKT
VMTVLGAFVVCWTPGLVVLLLDGLNCRQCGVQHVKRWFLLLALLNSVVNPIIYSYKDEDM
YGTMKKMICCFSQENPERRPSRIPSTVLSRSDTGSQYIEDSISQGAVCNKSTS
|
| External Links |
|---|
| GenBank ID Protein
| 5922725 |
| UniProtKB/Swiss-Prot ID
| Q9UBY5 |
| UniProtKB/Swiss-Prot Entry Name
| LPAR3_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF127138 |
| GeneCard ID
| LPAR3 |
| GenAtlas ID
| LPAR3 |
| HGNC ID
| HGNC:14298 |
| References |
|---|
| General References
| Not Available |