| Identification |
|---|
| HMDB Protein ID
| CDBP02093 |
| Secondary Accession Numbers
| Not Available |
| Name
| Ceramide synthase 1 |
| Description
| Not Available |
| Synonyms
|
- Longevity assurance gene 1 protein homolog 1
- Protein UOG-1
- CerS1
- LAG1 longevity assurance homolog 1
|
| Gene Name
| CERS1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in sphingosine N-acyltransferase activity |
| Specific Function
| May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing mainly one fatty acid donor (N-linked stearoyl- (C18) ceramide) in a fumonisin B1-independent manner (By similarity).
|
| GO Classification
|
| Biological Process |
| small molecule metabolic process |
| ceramide biosynthetic process |
| phospholipid metabolic process |
| Cellular Component |
| endoplasmic reticulum membrane |
| integral to membrane |
| Golgi membrane |
| Component |
| cell part |
| membrane part |
| intrinsic to membrane |
| integral to membrane |
| Molecular Function |
| sphingosine N-acyltransferase activity |
|
| Cellular Location
|
- Golgi apparatus membrane
- Multi-pass membrane protein
- Multi-pass membrane protein
- Isoform 1:Endoplasmic reticulum membrane
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| LASS1 |
| Gene Sequence
|
>1053 bp
ATGGCGGCGGCGGGGCCCGCGGCGGGGCCGACGGGGCCCGAGCCCATGCCGAGCTACGCG
CAGCTAGTGCAGCGCGGCTGGGGCAGCGCGCTGGCGGCGGCGCGGGGCTGCACGGACTGC
GGCTGGGGGCTGGCGCGTCGCGGCCTGGCTGAGCACGCGCACCTGGCGCCGCCCGAGCTG
CTGCTGCTGGCGCTCGGCGCGCTGGGCTGGACCGCCCTGCGCTCCGCGGCCACTGCGCGC
CTCTTTCGGCCCCTGGCGAAGCGGTGCTGCCTCCAGCCCAGAGATGCCGCCAAGATGCCC
GAGAGCGCTTGGAAGTTTCTCTTCTACCTGGGCAGCTGGAGCTACAGTGCCTACCTGCTG
TTTGGCACCGACTACCCCTTCTTCCATGACCCACCATCTGTCTTCTACGACTGGACGCCG
GGCATGGCAGTGCCACGGGACATTGCAGCCGCCTACCTGCTCCAGGGAAGCTTCTATGGC
CACTCCATCTACGCTACGCTATACATGGACACCTGGCGCAAGGACTCGGTGGTCATGCTG
CTCCACCACGTGGTCACTCTCATCCTCATCGTCTCCTCCTACGCCTTCCGGTACCACAAT
GTGGGCATCCTTGTGCTCTTCCTGCACGATATCAGTGACGTGCAGCTTGAGTTCACCAAG
CTCAACATTTACTTCAAGTCCCGCGGCGGCTCCTACCATCGGCTGCATGCCTTGGCAGCA
GACTTGGGCTGCCTCAGCTTCGGCTTCAGCTGGTTCTGGTTCCGCCTCTACTGGTTCCCG
CTCAAGGTCCTGTATGCCACCAGTCACTGCAGTCTGCGCACGGTGCCTGACATCCCCTTC
TACTTCTTCTTCAATGCGCTCCTGCTGCTGCTCACCCTTATGAACCTCTACTGGTTCCTG
TACATCGTGGCGTTTGCAGCCAAGGTGTTGACAGGCCAGGTGCACGAGCTGAAGGACCTG
CGGGAGTATGACACAGCCGAGGCCCAGAGCCTGAAGCCCAGCAAAGCCGAGAAGCCACTG
AGGAACGGCCTGGTGAAGGACAAGCGCTTCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 350 |
| Molecular Weight
| Not Available |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>LAG1 longevity assurance homolog 1
MAAAGPAAGPTGPEPMPSYAQLVQRGWGSALAAARGCTDCGWGLARRGLAEHAHLAPPEL
LLLALGALGWTALRSAATARLFRPLAKRCCLQPRDAAKMPESAWKFLFYLGSWSYSAYLL
FGTDYPFFHDPPSVFYDWTPGMAVPRDIAAAYLLQGSFYGHSIYATLYMDTWRKDSVVML
LHHVVTLILIVSSYAFRYHNVGILVLFLHDISDVQLEFTKLNIYFKSRGGSYHRLHALAA
DLGCLSFGFSWFWFRLYWFPLKVLYATSHCSLRTVPDIPFYFFFNALLLLLTLMNLYWFL
YIVAFAAKVLTGQVHELKDLREYDTAEAQSLKPSKAEKPLRNGLVKDKRF
|
| External Links |
|---|
| GenBank ID Protein
| 11641421 |
| UniProtKB/Swiss-Prot ID
| P27544 |
| UniProtKB/Swiss-Prot Entry Name
| LASS1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_021267.3 |
| GeneCard ID
| LASS1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| HGNC:14253 |
| References |
|---|
| General References
| Not Available |