| Identification |
|---|
| HMDB Protein ID
| CDBP01473 |
| Secondary Accession Numbers
| Not Available |
| Name
| Phosphatidylinositol-glycan-specific phospholipase D |
| Description
| Not Available |
| Synonyms
|
- GPI-PLD
- GPI-specific phospholipase D
- Glycoprotein phospholipase D
- Glycosyl-phosphatidylinositol-specific phospholipase D
- PI-G PLD
|
| Gene Name
| GPLD1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in glycosylphosphatidylinositol phospholipase D activity |
| Specific Function
| This protein hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans (GPI-anchor) thus releasing these proteins from the membrane.
|
| GO Classification
|
| Biological Process |
| positive regulation of cytolysis |
| positive regulation of glucose metabolic process |
| positive regulation of insulin secretion involved in cellular response to glucose stimulus |
| positive regulation of membrane protein ectodomain proteolysis |
| regulation of cellular response to insulin stimulus |
| positive regulation of apoptotic process |
| transepithelial transport |
| cellular response to calcium ion |
| positive regulation of high-density lipoprotein particle clearance |
| cellular response to drug |
| cellular response to cholesterol |
| cellular response to pH |
| insulin receptor signaling pathway |
| cell migration involved in sprouting angiogenesis |
| positive regulation of endothelial cell migration |
| cellular response to triglyceride |
| chondrocyte differentiation |
| phosphatidylcholine metabolic process |
| complement receptor mediated signaling pathway |
| positive regulation of triglyceride biosynthetic process |
| GPI anchor release |
| response to glucose stimulus |
| hematopoietic stem cell migration to bone marrow |
| ossification |
| negative regulation of triglyceride catabolic process |
| negative regulation of cell proliferation |
| positive regulation of alkaline phosphatase activity |
| Cellular Component |
| proteinaceous extracellular matrix |
| extracellular space |
| intracellular membrane-bounded organelle |
| cytoplasmic part |
| Component |
| extracellular region |
| Function |
| hydrolase activity, acting on ester bonds |
| catalytic activity |
| hydrolase activity |
| phospholipase d activity |
| glycosylphosphatidylinositol phospholipase d activity |
| lipase activity |
| phospholipase activity |
| Molecular Function |
| glycosylphosphatidylinositol phospholipase D activity |
| sodium channel regulator activity |
|
| Cellular Location
|
- Secreted
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 6 |
| Locus
| 6p22.1 |
| SNPs
| GPLD1 |
| Gene Sequence
|
>2523 bp
ATGTCTGCTTTCAGGTTGTGGCCTGGCCTGCTGATCATGTTGGGTTCTCTCTGCCATAGA
GGTTCACCGTGTGGCCTTTCAACACACATAGAAATAGGACACAGAGCTCTGGAGTTTCTT
CAGCTTCACAATGGGCGTGTTAACTACAGAGAGCTGTTACTAGAACACCAGGATGCGTAT
CAGGCTGGAATCGTGTTTCCTGATTGTTTTTACCCTAGCATCTGCAAAGGAGGAAAATTC
CATGATGTGTCTGAGAGCACTCACTGGACTCCGTTTCTTAATGCAAGCGTTCATTATATC
CGAGAGAACTATCCCCTTCCCTGGGAGAAGGACACAGAGAAACTGGTAGCTTTCTTGTTT
GGAATTACTTCTCACATGGCGGCAGATGTCAGCTGGCATAGTCTGGGCCTTGAACAAGGA
TTCCTTAGGACCATGGGAGCTATTGATTTTCACGGCTCCTATTCAGAGGCTCATTCGGCT
GGTGATTTTGGAGGAGATGTGTTGAGCCAGTTTGAATTTAATTTTAATTACCTTGCACGA
CGCTGGTATGTGCCAGTCAAAGATCTACTGGGAATTTATGAGAAACTGTATGGTCGAAAA
GTCATCACCGAAAATGTAATCGTTGATTGTTCACATATCCAGTTCTTAGAAATGTATGGT
GAGATGCTAGCTGTTTCCAAGTTATATCCCACTTACTCTACAAAGTCCCCGTTTTTGGTG
GAACAATTCCAAGAGTATTTTCTTGGAGGACTGGATGATATGGCATTTTGGTCCACTAAT
ATTTACCATCTAACAAGCTTCATGTTGGAGAATGGGACCAGTGACTGCAACCTGCCTGAG
AACCCTCTGTTCATTGCATGTGGCGGCCAGCAAAACCACACCCAGGGCTCAAAAATGCAG
AAAAATGATTTTCACAGAAATTTGACTACATCCCTAACTGAAAGTGTTGACAGGAATATA
AACTATACTGAAAGAGGAGTGTTCTTTAGTGTAAATTCCTGGACCCCGGATTCCATGTCC
TTTATCTACAAGGCTTTGGAAAGGAACATAAGGACAATGTTCATAGGTGGCTCTCAGTTG
TCACAAAAGCACGTCTCCAGCCCCTTAGCATCTTACTTCTTGTCATTTCCTTATGCGAGG
CTTGGCTGGGCAATGACCTCAGCTGACCTCAACCAGGATGGGCACGGTGACCTCGTGGTG
GGCGCACCAGGCTACAGCCGCCCCGGCCACATCCACATCGGGCGCGTGTACCTCATCTAC
GGCAATGACCTGGGCCTGCCACCTGTTGACCTGGACCTGGACAAGGAGGCCCACAGGATC
CTTGAAGGCTTCCAGCCCTCAGGTCGGTTTGGCTCGGCCTTGGCTGTGTTGGACTTTAAC
GTGGACGGCGTGCCTGACCTGGCCGTGGGAGCTCCCTCGGTGGGCTCCGAGCAGCTCACC
TACAAAGGTGCCGTGTATGTCTACTTTGGTTCCAAACAAGGAGGAATGTCTTCTTCCCCT
AACATCACCATTTCTTGCCAGGACATCTACTGTAACTTGGGCTGGACTCTCTTGGCTGCA
GATGTGAATGGAGACAGTGAACCCGATCTGGTCATCGGCTCCCCTTTTGCACCAGGTGGA
GGGAAGCAGAAGGGAATTGTGGCTGCGTTTTATTCTGGCCCCAGCCTGAGCGACAAAGAA
AAACTGAACGTGGAGGCAGCCAACTGGACGGTGAGAGGCGAGGAAGACTTCTCCTGGTTT
GGATATTCCCTTCACGGTGTCACTGTGGACAACAGAACCTTGCTGTTGGTTGGGAGCCCG
ACCTGGAAGAATGCCAGCAGGCTGGGCCATTTGTTACACATCCGAGATGAGAAAAAGAGC
CTTGGGAGGGTGTATGGCTACTTCCCACCAAACGGCCAAAGCTGGTTTACCATTTCTGGA
GACAAGGCAATGGGGAAACTGGGTACTTCCCTTTCCAGTGGCCACGTACTGATGAATGGG
ACTCTGAAACAAGTGCTGCTGGTTGGAGCCCCTACGTACGATGACGTGTCTAAGGTGGCA
TTCCTGACCGTGACCCTACACCAAGGCGGAGCCACTCGCATGTACGCACTCATATCTGAC
GCGCAGCCTCTGCTGCTCAGCACCTTCAGCGGAGACCGCCGCTTCTCCCGATTTGGTGGC
GTTCTGCACTTGAGTGACCTGGATGATGATGGCTTAGATGAAATCATCATGGCAGCCCCC
CTGAGGATAGCAGATGTAACCTCTGGACTGATTGGGGGAGAAGACGGCCGAGTATATGTA
TATAATGGCAAAGAGACCACCCTTGGTGACATGACTGGCAAATGCAAATCATGGATAACT
CCATGTCCAGAAGAAAAGGCCCAATATGTATTGATTTCTCCTGAAGCCAGCTCAAGGTTT
GGGAGCTCCCTCATCACCGTGAGGTCCAAGGCAAAGAACCAAGTCGTCATTGCTGCTGGA
AGGAGTTCTTTGGGAGCCCGACTCTCCGGGGCACTTCACGTCTATAGCCTTGGCTCAGAT
TGA
|
| Protein Properties |
|---|
| Number of Residues
| 840 |
| Molecular Weight
| 92335.705 |
| Theoretical pI
| 6.362 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Phosphatidylinositol-glycan-specific phospholipase D
MSAFRLWPGLLIMLGSLCHRGSPCGLSTHVEIGHRALEFLQLHNGRVNYRELLLEHQDAY
QAGIVFPDCFYPSICKGGKFHDVSESTHWTPFLNASVHYIRENYPLPWEKDTEKLVAFLF
GITSHMAADVSWHSLGLEQGFLRTMGAIDFHGSYSEAHSAGDFGGDVLSQFEFNFNYLAR
RWYVPVKDLLGIYEKLYGRKVITENVIVDCSHIQFLEMYGEMLAVSKLYPTYSTKSPFLV
EQFQEYFLGGLDDMAFWSTNIYHLTSFMLENGTSDCNLPENPLFIACGGQQNHTQGSKMQ
KNDFHRNLTTSLTESVDRNINYTERGVFFSVNSWTPDSMSFIYKALERNIRTMFIGGSQL
SQKHVSSPLASYFLSFPYARLGWAMTSADLNQDGHGDLVVGAPGYSRPGHIHIGRVYLIY
GNDLGLPPVDLDLDKEAHRILEGFQPSGRFGSALAVLDFNVDGVPDLAVGAPSVGSEQLT
YKGAVYVYFGSKQGGMSSSPNITISCQDIYCNLGWTLLAADVNGDSEPDLVIGSPFAPGG
GKQKGIVAAFYSGPSLSDKEKLNVEAANWTVRGEEDFSWFGYSLHGVTVDNRTLLLVGSP
TWKNASRLGHLLHIRDEKKSLGRVYGYFPPNGQSWFTISGDKAMGKLGTSLSSGHVLMNG
TLKQVLLVGAPTYDDVSKVAFLTVTLHQGGATRMYALTSDAQPLLLSTFSGDRRFSRFGG
VLHLSDLDDDGLDEIIMAAPLRIADVTSGLIGGEDGRVYVYNGKETTLGDMTGKCKSWIT
PCPEEKAQYVLISPEASSRFGSSLITVRSKAKNQVVIAAGRSSLGARLSGALHVYSLGSD
|
| External Links |
|---|
| GenBank ID Protein
| 20269065 |
| UniProtKB/Swiss-Prot ID
| P80108 |
| UniProtKB/Swiss-Prot Entry Name
| PHLD_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AJ308108 |
| GeneCard ID
| GPLD1 |
| GenAtlas ID
| GPLD1 |
| HGNC ID
| HGNC:4459 |
| References |
|---|
| General References
| Not Available |