| Identification |
|---|
| HMDB Protein ID
| CDBP01018 |
| Secondary Accession Numbers
| Not Available |
| Name
| Acid ceramidase |
| Description
| Not Available |
| Synonyms
|
- AC
- Acid ceramidase subunit alpha
- Acid ceramidase subunit beta
- Acylsphingosine deacylase
- N-acylsphingosine amidohydrolase
- PHP32
- Putative 32 kDa heart protein
- ACDase
- Acid CDase
|
| Gene Name
| ASAH1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in lipid metabolic process |
| Specific Function
| Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.
|
| GO Classification
|
| Biological Process |
| small molecule metabolic process |
| phospholipid metabolic process |
| ceramide metabolic process |
| response to organic substance |
| lung development |
| glycosphingolipid metabolic process |
| cell death |
| Cellular Component |
| lysosomal lumen |
| Component |
| organelle |
| membrane-bounded organelle |
| intracellular membrane-bounded organelle |
| vacuole |
| lytic vacuole |
| lysosome |
| Molecular Function |
| ceramidase activity |
| Process |
| metabolic process |
| primary metabolic process |
| lipid metabolic process |
|
| Cellular Location
|
- Lysosome
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Lysosome | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 8 |
| Locus
| 8p22 |
| SNPs
| ASAH1 |
| Gene Sequence
|
>1188 bp
ATGCCGGGCCGGAGTTGCGTCGCCTTAGTCCTCCTGGCTGCCGCCGTCAGCTGTGCCGTC
GCGCAGCACGCGCCGCCGTGGACAGAGGACTGCAGAAAATCAACCTATCCTCCTTCAGGA
CCAACGTACAGAGGTGCAGTTCCATGGTACACCATAAATCTTGACTTACCACCCTACAAA
AGATGGCATGAATTGATGCTTGACAAGGCACCAGTGCTAAAGGTTATAGTGAATTCTCTG
AAGAATATGATAAATACATTCGTGCCAAGTGGAAAAATTATGCAGGTGGTGGATGAAAAA
TTGCCTGGCCTACTTGGCAACTTTCCTGGCCCTTTTGAAGAGGAAATGAAGGGTATTGCC
GCTGTTACTGATATACCTTTAGGAGAGATTATTTCATTCAATATTTTTTATGAATTATTT
ACCATTTGTACTTCAATAGTAGCAGAAGACAAAAAAGGTCATCTAATACATGGGAGAAAC
ATGGATTTTGGAGTATTTCTTGGGTGGAACATAAATAATGATACCTGGGTCATAACTGAG
CAACTAAAACCTTTAACAGTGAATTTGGATTTCCAAAGAAACAACAAAACTGTCTTCAAG
GCTTCAAGCTTTGCTGGCTATGTGGGCATGTTAACAGGATTCAAACCAGGACTGTTCAGT
CTTACACTGAATGAACGTTTCAGTATAAATGGTGGTTATCTGGGTATTCTAGAATGGATT
CTGGGAAAGAAAGATGTCATGTGGATAGGGTTCCTCACTAGAACAGTTCTGGAAAATAGC
ACAAGTTATGAAGAAGCCAAGAATTTATTGACCAAGACCAAGATATTGGCCCCAGCCTAC
TTTATCCTGGGAGGCAACCAGTCTGGGGAAGGTTGTGTGATTACACGAGACAGAAAGGAA
TCATTGGATGTATATGAACTCGATGCTAAGCAGGGTAGATGGTATGTGGTACAAACAAAT
TATGACCGTTGGAAACATCCCTTCTTCCTTGATGATCGCAGAACGCCTGCAAAGATGTGT
CTGAACCGCACCAGCCAAGAGAATATCTCATTTGAAACCATGTATGATGTCCTGTCAACA
AAACCTGTCCTCAACAAGCTGACCGTATACACAACCTTGATAGATGTTACCAAAGGTCAA
TTCGAAACTTACCTGCGGGACTGCCCTGACCCTTGTATAGGTTGGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 395 |
| Molecular Weight
| 44045.27 |
| Theoretical pI
| 7.616 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Acid ceramidase
MPGRSCVALVLLAAAVSCAVAQHAPPWTEDCRKSTYPPSGPTYRGAVPWYTINLDLPPYK
RWHELMLDKAPVLKVIVNSLKNMINTFVPSGKIMQVVDEKLPGLLGNFPGPFEEEMKGIA
AVTDIPLGEIISFNIFYELFTICTSIVAEDKKGHLIHGRNMDFGVFLGWNINNDTWVITE
QLKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILEWI
LGKKDVMWIGFLTRTVLENSTSYEEAKNLLTKTKILAPAYFILGGNQSGEGCVITRDRKE
SLDVYELDAKQGRWYVVQTNYDRWKHPFFLDDRRTPAKMCLNRTSQENISFETMYDVLST
KPVLNKLTVYTTLIDVTKGQFETYLRDCPDPCIGW
|
| External Links |
|---|
| GenBank ID Protein
| 189011548 |
| UniProtKB/Swiss-Prot ID
| Q13510 |
| UniProtKB/Swiss-Prot Entry Name
| ASAH1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_177924.3 |
| GeneCard ID
| ASAH1 |
| GenAtlas ID
| ASAH1 |
| HGNC ID
| HGNC:735 |
| References |
|---|
| General References
| Not Available |