Showing Protein Aldo-keto reductase family 1 member C3 (CDBP00353)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 7 compounds
Identification
HMDB Protein ID CDBP00353
Secondary Accession Numbers Not Available
Name Aldo-keto reductase family 1 member C3
Description Not Available
Synonyms
  1. 17-beta-HSD 5
  2. 17-beta-hydroxysteroid dehydrogenase type 5
  3. 3-alpha-HSD type 2
  4. 3-alpha-HSD type II, brain
  5. 3-alpha-hydroxysteroid dehydrogenase type 2
  6. Chlordecone reductase homolog HAKRb
  7. DD-3
  8. DD3
  9. Dihydrodiol dehydrogenase 3
  10. Dihydrodiol dehydrogenase type I
  11. HA1753
  12. Indanol dehydrogenase
  13. PGFS
  14. Prostaglandin F synthase
  15. Testosterone 17-beta-dehydrogenase 5
  16. Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
Gene Name AKR1C3
Protein Type Enzyme
Biological Properties
General Function Involved in oxidoreductase activity
Specific Function Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.
GO Classification
Biological Process
cellular response to cadmium ion
cellular response to corticosteroid stimulus
cellular response to prostaglandin stimulus
positive regulation of reactive oxygen species metabolic process
cellular response to reactive oxygen species
cellular response to calcium ion
cellular response to starvation
keratinocyte differentiation
male gonad development
positive regulation of cell proliferation
multicellular organismal macromolecule metabolic process
negative regulation of retinoic acid biosynthetic process
response to nutrient
positive regulation of endothelial cell apoptotic process
prostaglandin metabolic process
protein import into nucleus, translocation
daunorubicin metabolic process
regulation of retinoic acid receptor signaling pathway
doxorubicin metabolic process
regulation of testosterone biosynthetic process
farnesol catabolic process
renal absorption
cellular response to jasmonic acid stimulus
testosterone biosynthetic process
progesterone metabolic process
retinal metabolic process
positive regulation of protein kinase B signaling cascade
Cellular Component
cytoplasm
nucleus
Function
catalytic activity
oxidoreductase activity
Molecular Function
dihydrotestosterone 17-beta-dehydrogenase activity
ketoreductase activity
alditol:NADP+ 1-oxidoreductase activity
prostaglandin D2 11-ketoreductase activity
prostaglandin-F synthase activity
retinol dehydrogenase activity
testosterone 17-beta-dehydrogenase (NADP+) activity
geranylgeranyl reductase activity
testosterone dehydrogenase (NAD+) activity
indanol dehydrogenase activity
retinal dehydrogenase activity
ketosteroid monooxygenase activity
oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor
phenanthrene 9,10-monooxygenase activity
trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
androsterone dehydrogenase (A-specific) activity
prostaglandin F receptor activity
15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity
androsterone dehydrogenase activity
delta4-3-oxosteroid 5beta-reductase activity
Process
metabolic process
oxidation reduction
Cellular Location
  1. Cytoplasm
Pathways
Gene Properties
Chromosome Location 10
Locus 10p15-p14
SNPs AKR1C3
Gene Sequence 
>972 bp
ATGGATTCCAAACAGCAGTGTGTAAAGCTAAATGATGGCCACTTCATGCCTGTATTGGGA
TTTGGCACCTATGCACCTCCAGAGGTTCCGAGAAGTAAAGCTTTGGAGGTCACAAAATTA
GCAATAGAAGCTGGGTTCCGCCATATAGATTCTGCTCATTTATACAATAATGAGGAGCAG
GTTGGACTGGCCATCCGAAGCAAGATTGCAGATGGCAGTGTGAAGAGAGAAGACATATTC
TACACTTCAAAGCTTTGGTCCACTTTTCATCGACCAGAGTTGGTCCGACCAGCCTTGGAA
AACTCACTGAAAAAAGCTCAATTGGACTATGTTGACCTCTATCTTATTCATTCTCCAATG
TCTCTAAAGCCAGGTGAGGAACTTTCACCAACAGATGAAAATGGAAAAGTAATATTTGAC
ATAGTGGATCTCTGTACCACCTGGGAGGCCATGGAGAAGTGTAAGGATGCAGGATTGGCC
AAGTCCATTGGGGTGTCAAACTTCAACCGCAGGCAGCTGGAGATGATCCTCAACAAGCCA
GGACTCAAGTACAAGCCTGTCTGCAACCAGGTAGAATGTCATCCGTATTTCAACCGGAGT
AAATTGCTAGATTTCTGCAAGTCGAAAGATATTGTTCTGGTTGCCTATAGTGCTCTGGGA
TCTCAACGAGACAAACGATGGGTGGACCCGAACTCCCCGGTGCTCTTGGAGGACCCAGTC
CTTTGTGCCTTGGCAAAAAAGCACAAGCGAACCCCAGCCCTGATTGCCCTGCGCTACCAG
CTGCAGCGTGGGGTTGTGGTCCTGGCCAAGAGCTACAATGAGCAGCGCATCAGACAGAAC
GTGCAGGTTTTTGAGTTCCAGTTGACTGCAGAGGACATGAAAGCCATAGATGGCCTAGAC
AGAAATCTCCACTATTTTAACAGTGATAGTTTTGCTAGCCACCCTAATTATCCATATTCA
GATGAATATTAA
Protein Properties
Number of Residues 323
Molecular Weight 36866.91
Theoretical pI 7.948
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence 
>Aldo-keto reductase family 1 member C3
MDSKHQCVKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQ
VGLAIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPM
SLKPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKP
GLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPV
LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLD
RNLHYFNSDSFASHPNYPYSDEY
GenBank ID Protein 6624211
UniProtKB/Swiss-Prot ID P42330
UniProtKB/Swiss-Prot Entry Name AK1C3_HUMAN
PDB IDs
GenBank Gene ID AB018580
GeneCard ID AKR1C3
GenAtlas ID AKR1C3
HGNC ID HGNC:386
References
General References Not Available